Evidence-Based Diagnostics

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Levels of Evidence

Levels of Evidence: Studies of Diagnostic Accuracy

Level Criteria
1 Independent, masked comparison with reference standard among an appropriate population of consecutive patients
2 Independent, masked comparison with reference standard among non-consecutive patients or confined to a narrow population of study patients
3 Independent, masked comparison with reference standard among non-consecutive patients or confined to a narrow population of study patients
4 Reference standard not applied independently or masked
5 Expert opinion with no explicit critical appraisal, based on physiology, bench research, or first principles

Source: Evidence and Diagnostics (Bandolier)

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Site Host
University of Oxford
British Medical Journal 2005;330:724-726 
University of Nottingham