| Level |
Criteria |
| 1 |
Independent, masked comparison with reference standard among an appropriate population of consecutive patients |
| 2 |
Independent, masked comparison with reference standard among non-consecutive patients or confined to a narrow population of study patients |
| 3 |
Independent, masked comparison with reference standard among non-consecutive patients or confined to a narrow population of study patients |
| 4 |
Reference standard not applied independently or masked |
| 5 |
Expert opinion with no explicit critical appraisal, based on physiology, bench research, or first principles |